氨基酸转运载体-简单介绍

氨基酸转运载体-简单介绍

CD98 

CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.

rBAT

系统b0, +和y+L的蛋白质属于异二聚体结构, 由重链和轻链组合发挥其转运功能, 均属于反相交换转运机制。系统 b0, +主要在肠道和肾小管上皮细胞顶端表达 ,主要从肠腔面吸收碱性氨基酸和胱氨酸,转出中性氨基酸,其重链为rBAT,轻链为SLC7A9

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